Acute attacks
Sudden attacks of hereditary angioedema.
Clinical trials
Studies that evaluate the effectiveness and safety of medications or medical devices before they are approved for use by the general public.
Ecallantide (e-KAL-lan-tide)
A protein made in yeast cells; ecallantide is the active ingredient in KALBITOR (ecallantide).
HAE
Abbreviation for hereditary angioedema.
Hereditary Angioedema
A rare, hereditary disease of the immune system that causes attacks of sudden swelling in various parts of the body.
KALBITOR Access®
KALBITOR Access is a program that provides support services to hereditary angioedema patients, healthcare professionals and caregivers. KALBITOR Access services include health insurance coordination, financial assistance for qualified patients, and treatment location set up.
KALBITOR CareSM
KALBITOR Care is a program offered by Dyax Corp. that provides comprehensive support services for KALBITOR patients. Available 24 hours a day, 7 days a week, KALBITOR Care offers a complete array of patient services and resources, along with the support of healthcare professionals.
KALBITOR Home Infusion ServicesSM
KALBITOR Home Infusion Services is a program in which an experienced infusion nurse will administer your subcutaneous KALBITOR treatment in the comfort of your own home. This professional service is available to HAE patients, 16 years of age or older, who use KALBITOR to treat their sudden HAE attacks on demand. KALBITOR Home Infusion Services is not appropriate for treating laryngeal attacks.
KALBITOR® (KAL-bit-or)
A prescription medicine used to treat sudden attacks of hereditary angioedema in patients 16 years of age and older. KALBITOR® is not a cure for HAE.
Laryngeal attack
An HAE attack that affects the larynx (throat); this can block or close the airway, leading to difficulty breathing and, potentially, death.
Larynx
The part of the throat that contains the vocal cords and is used for breathing, swallowing, and talking.
On-demand treatment
On-demand HAE treatment is used to treat sudden attacks of HAE as they occur, in order to relieve symptoms associated with the attack. On-demand treatment is not used to prevent attacks from occurring.
Plasma kallikrein (kal'i-kre'in)
A protein in the body that triggers the release of a substance that may lead to hereditary angioedema attack symptoms.
Subcutaneous
Under the skin.
Trigger
In hereditary angioedema, something that causes an attack.
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Should I just wait this attack out?

That was my first question. Now I know that I have KALBITOR® (ecallantide), an on-demand treatment for my sudden HAE attacks, available to me with the help of KALBITOR Care®.

Please see Full Prescribing Information, including Boxed Warning and Medication Guide.

How KALBITOR Works

What is KALBITOR?

KALBITOR is an on-demand treatment approved to treat sudden hereditary angioedema (HAE) attacks in patients 16 years of age and older. KALBITOR is not a cure for HAE. It is administered through a series of three injections just under the skin. 

A Different Kind of HAE Therapy

A typical HAE attack can last from 2 to 5 days without treatment. On-demand treatment with KALBITOR has been proven to improve the symptoms of a sudden HAE attack at 4 hours and may reduce the need for other medications to treat attacks.

KALBITOR is the only subcutaneous treatment that targets and blocks plasma kallikrein, the source of sudden HAE attacks.

How Does KALBITOR Work?

KALBITOR blocks the activity of a protein in the body called plasma kallikrein. In patients with HAE, plasma kallikrein activity is not controlled properly.  


 During an HAE Attack:

  • Your body's levels of activated plasma kallikrein are increased
  • The increased levels of plasma kallikrein:
    — Activate a cycle that generates additional activated plasma kallikrien
    — Trigger the release of a chemical that causes veins to leak fluid
  • Leaked fluid results in swelling and pain

After the KALBITOR Injection:

  • KALBITOR blocks plasma kallikrein
  • Blocking plasma kallikrein:
    — Prevents the release of the chemical that causes veins to leak fluid, allowing the pain and swelling associated with your sudden HAE attack to improve
    — Breaks the cycle of continuous plasma kallikrein activation

Proven Results

KALBITOR was approved in 2009 and has a demonstrated safety record.

In clinical trials, 3.9% of patients treated both subcutaneously and intravenously with KALBITOR experienced serious allergic reactions. Within an hour, of all these cases were successfully managed by a healthcare professional.

Most patients treated with KALBITOR experienced: 

  • Significant improvement in sudden HAE attack symptoms at 4 hours
  • Sustained improvement of symptoms through 24 hours 
VIDEO: Joan's Experience with KALBITOR
"My first treatment of KALBITOR was during a laryngeal attack."

  

About KALBITOR Injections

KALBITOR injections should only be given by a doctor or a nurse with appropriate medical support to manage serious allergic reactions and HAE. Your doctor or nurse will inject KALBITOR just under your skin, typically in your abdomen, thigh, or upper arm.

KALBITOR is not a blood product. Its active ingredient is ecallantide, a small protein made in yeast cells.

Serious allergic reactions have been known to occur in patients treated with KALBITOR. See potential side effects. 

Please read the Medication Guide before you start receiving KALBITOR and before each treatment. There may be new information. 

 

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Please make sure to read
Important Safety
Information for KALBITOR.

safety information

Read stories from real HAE patients about their experiences with KALBITOR.  

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Upcoming doctor's appointment? Fill out the "Doctor Discussion Guide" to help discuss your HAE treatment needs with your doctor.

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KALBITOR is a prescription medicine used to treat sudden attacks of hereditary angioedema (HAE) in patients 16 years of age and older. KALBITOR is not a cure for HAE.
Important Safety Information EXPAND ›

KALBITOR® (ecallantide) for subcutaneous use should only be given by a doctor or nurse with appropriate medical support to treat serious allergic reactions and your hereditary angioedema. You should read the Medication Guide before you start receiving KALBITOR and before each treatment.

Serious allergic reactions may happen in some people who receive KALBITOR. These allergic reactions can be life-threatening and usually happen within 1 hour after receiving KALBITOR.

Symptoms of a serious allergic reaction to KALBITOR can be similar to the symptoms of hereditary angioedema, the condition that you are being treated for. Your doctor or nurse should watch you for any signs of a serious allergic reaction after treatment with KALBITOR. Tell your doctor or nurse right away if you have any of these symptoms of a serious allergic reaction during or after treatment with KALBITOR:

  • wheezing, shortness of breath, cough, chest tightness, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat, or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing
  • runny nose or sneezing

Do not receive KALBITOR if you are allergic to KALBITOR. Before receiving KALBITOR, tell your doctor if you have ever had an allergic reaction to KALBITOR.

Before receiving KALBITOR, tell your doctor about all of your health conditions, including any allergies you may have, whether you are pregnant, plan to become pregnant, or are breast feeding or plan to breast feed. It is not known if KALBITOR will harm your unborn baby or if KALBITOR passes into your breast milk.

Common side effects of KALBITOR include headache, nausea, diarrhea, fever, injection site reactions, such as redness, rash, swelling, itching, or bruising, and stuffy nose.

Talk to your doctor for more information and if you have any questions about your treatment.

Please see Full Prescribing Information, including Boxed Warning and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.