Acute attacks
Sudden attacks of hereditary angioedema.
Clinical trials
Studies that evaluate the effectiveness and safety of medications or medical devices before they are approved for use by the general public.
Ecallantide (e-KAL-lan-tide)
A protein made in yeast cells; ecallantide is the active ingredient in KALBITOR (ecallantide).
HAE
Abbreviation for hereditary angioedema.
Hereditary Angioedema
A rare, hereditary disease of the immune system that causes attacks of sudden swelling in various parts of the body.
KALBITOR Access®
KALBITOR Access is a program that provides support services to hereditary angioedema patients, healthcare professionals and caregivers. KALBITOR Access services include health insurance coordination, financial assistance for qualified patients, and treatment location set up.
KALBITOR CareSM
KALBITOR Care is a program offered by Dyax Corp. that provides comprehensive support services for KALBITOR patients. Available 24 hours a day, 7 days a week, KALBITOR Care offers a complete array of patient services and resources, along with the support of healthcare professionals.
KALBITOR Home Infusion ServicesSM
KALBITOR Home Infusion Services is a program in which an experienced infusion nurse will administer your subcutaneous KALBITOR treatment in the comfort of your own home. This professional service is available to HAE patients, 16 years of age or older, who use KALBITOR to treat their sudden HAE attacks on demand. KALBITOR Home Infusion Services is not appropriate for treating laryngeal attacks.
KALBITOR® (KAL-bit-or)
A prescription medicine used to treat sudden attacks of hereditary angioedema in patients 16 years of age and older. KALBITOR® is not a cure for HAE.
Laryngeal attack
An HAE attack that affects the larynx (throat); this can block or close the airway, leading to difficulty breathing and, potentially, death.
Larynx
The part of the throat that contains the vocal cords and is used for breathing, swallowing, and talking.
On-demand treatment
On-demand HAE treatment is used to treat sudden attacks of HAE as they occur, in order to relieve symptoms associated with the attack. On-demand treatment is not used to prevent attacks from occurring.
Plasma kallikrein (kal'i-kre'in)
A protein in the body that triggers the release of a substance that may lead to hereditary angioedema attack symptoms.
Subcutaneous
Under the skin.
Trigger
In hereditary angioedema, something that causes an attack.
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Should I just wait this attack out?

That was my first question. Now I know that I have KALBITOR® (ecallantide), an on-demand treatment for my sudden HAE attacks, available to me with the help of KALBITOR CareSM.

Please see Full Prescribing Information, including Boxed Warning and Medication Guide.

Danielle's Story

Results from treatment with KALBITOR may vary. Talk to your doctor to find out if KALBITOR is right for you. Make sure to read KALBITOR Important Safety Information regarding serious allergic reactions and review the Medication Guide before getting treatment with KALBITOR.

"I can relax and be who I am. I am not defined by my disease."

Danielle, 41, is a stay-at-home mom who lives with her husband and five-year-old daughter in Seattle. Danielle began to have severe hereditary angioedema (HAE) attacks when she was pregnant. She was diagnosed with HAE just before her 40th birthday.

"Attacks can happen at the worst possible times—late at night, or on a holiday, or when I'm home alone," Danielle explains. "When you're about to give birth, everyone tells you to be prepared to get to the hospital; I think living with HAE is similar. I started to take KALBITOR for my acute HAE attacks as soon as it became available. I have a letter from my doctor explaining my condition and treatments. I have different routes to get to the nearest emergency room. I have an overnight bag packed and put away. I have everything set up so that I can live my life as normally as I can, knowing that I am prepared."

New Horizons

Being away from her home, far from her regular treatment facility, was nerve-wracking for Danielle. The uncertainty of where to go for treatment made it difficult to travel. So when Danielle learned from her doctor that KALBITOR could be shipped directly to a patient's home, she was very excited.

The process for getting KALBITOR shipped to her home was simple, Danielle adds. "My doctor's office filled out the paperwork and sent it to KALBITOR Access®, which worked directly with my doctor and insurance company. Before I received my shipment, the KALBITOR Access nurse called to go over the details with me, including how to store KALBITOR and bring it to a pre-selected treatment site to be given to me. I have it in my refrigerator right now."

(KALBITOR is not approved for self-administration and should only be administered by a doctor or nurse with appropriate medical support to manage serious allergic reactions and HAE.)

Receiving KALBITOR at home has made life easier and more flexible for Danielle. When she's at home, she still visits her local hospital for treatment. But if she has to travel, she alerts her KALBITOR Access nurse, who sets up a treatment site for Danielle at her destination, in case of an emergency.

Alerting KALBITOR Access to her travel plans has made all the difference. She recalls: "Once, before a trip, my KALBITOR Access nurse made arrangements with a local hospital, where I could be treated with KALBITOR if I had an HAE attack. Sure enough, I had an attack at 4 a.m. I took a cab to that hospital, showed them the letter from my doctor, gave them my KALBITOR and got treated by the doctor. It all went smoothly.

"When I called KALBITOR Access to let them know I'd used one of my doses, they immediately overnighted another dose to me. They are so wonderful about giving me personalized care and making sure that I have my medicine when and where I need it."

New Possibilities

"Having KALBITOR at home has opened up so many more possibilities for me," she says. "My husband's family lives two hours away and I haven't been to their home because there wasn't a hospital nearby that stocked KALBITOR. Now, KALBITOR Access made it possible for me to bring my KALBITOR to a hospital a half-hour from where they live to get my injection. It's just wonderful—I'm going there for a holiday weekend soon.

"I'm getting so adventurous now," Danielle laughs. "I don't have the same fears. Before this option, I'd panic if I was more than a half-hour from my local ER. Now, I feel more prepared and have greater peace of mind, because with the help of KALBITOR Access I make sure that there is always a place for me to get treated, should it be necessary."

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KALBITOR is a prescription medicine used to treat sudden attacks of hereditary angioedema (HAE) in patients 16 years of age and older. KALBITOR is not a cure for HAE.
Important Safety Information EXPAND ›

KALBITOR® (ecallantide) for subcutaneous use should only be given by a doctor or nurse with appropriate medical support to treat serious allergic reactions and your hereditary angioedema. You should read the Medication Guide before you start receiving KALBITOR and before each treatment.

Serious allergic reactions may happen in some people who receive KALBITOR. These allergic reactions can be life-threatening and usually happen within 1 hour after receiving KALBITOR.

Symptoms of a serious allergic reaction to KALBITOR can be similar to the symptoms of hereditary angioedema, the condition that you are being treated for. Your doctor or nurse should watch you for any signs of a serious allergic reaction after treatment with KALBITOR. Tell your doctor or nurse right away if you have any of these symptoms of a serious allergic reaction during or after treatment with KALBITOR:

  • wheezing, shortness of breath, cough, chest tightness, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat, or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing
  • runny nose or sneezing

Do not receive KALBITOR if you are allergic to KALBITOR. Before receiving KALBITOR, tell your doctor if you have ever had an allergic reaction to KALBITOR.

Before receiving KALBITOR, tell your doctor about all of your health conditions, including any allergies you may have, whether you are pregnant, plan to become pregnant, or are breast feeding or plan to breast feed. It is not known if KALBITOR will harm your unborn baby or if KALBITOR passes into your breast milk.

Common side effects of KALBITOR include headache, nausea, diarrhea, fever, injection site reactions, such as redness, rash, swelling, itching, or bruising, and stuffy nose.

Talk to your doctor for more information and if you have any questions about your treatment.

Please see Full Prescribing Information, including Boxed Warning and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.