How HAE Attacks Happen

A protein in the body called plasma kallikrein (kal′i-kre′in) triggers the release of a substance that may lead to acute hereditary angioedema attack symptoms. In patients with HAE, plasma kallikrein activity is not controlled properly.

During an acute HAE attack:

  • Levels of activated plasma kallikrein are increased within the body
  • This triggers a release of a substance that causes veins to leak fluid
  • Leaked fluid builds up in the tissues just under the skin in various parts of the body
  • This causes the swelling and pain of an acute HAE attack


KALBITOR Is Proven Effective for Acute HAE Attacks

KALBITOR is the first under the skin (subcutaneous) treatment approved for sudden attacks of hereditary angioedema in patients 16 years of age and older. KALBITOR is not a cure for HAE.

KALBITOR was proven effective in clinical trials to improve symptoms of acute HAE attacks. In clinical studies, most patients treated with KALBITOR had:

  • Reduction in acute attack symptoms at 4 hours
  • Sustained improvement of symptoms at 24 hours

Learn how KALBITOR treats acute HAE attacks by blocking plasma kallikrein.