Where HAE Attacks Happen

Hereditary angioedema (HAE) attacks typically happen in three main places in the body, causing swelling of the:

Peripheral areas, including the face, hands, feet and genitals (sex organs)

Abdomen (stomach)

Larynx (throat)

Attacks sometimes affect just one part of the body, such as swelling only in the face. But it's not uncommon for some people to have attacks in more than one place at a time, such as swelling in the face as well as in the abdomen.

KALBITOR is the first under the skin (subcutaneous) treatment approved for sudden attacks of hereditary angioedema in patients 16 years of age and older. KALBITOR is not a cure for HAE.

KALBITOR is approved for all attack locations including the face, hands, feet, genitals, abdomen and throat. Learn more about how KALBITOR works.

Important Safety Information

KALBITOR^® (ecallantide) for subcutaneous use should only be given by a doctor or nurse with appropriate medical support to treat serious allergic reactions and your hereditary angioedema. You should read the Medication Guide before you start receiving KALBITOR and before each treatment.

Serious allergic reactions may happen in some people who receive KALBITOR. These allergic reactions can be life-threatening and usually happen within 1 hour after receiving KALBITOR.

Symptoms of a serious allergic reaction to KALBITOR can be similar to the symptoms of hereditary angioedema, the condition that you are being treated for. Your doctor or nurse should watch you for any signs of a serious allergic reaction after treatment with KALBITOR. Tell your doctor or nurse right away if you have any of these symptoms of a serious allergic reaction during or after treatment with KALBITOR:

wheezing, shortness of breath, cough, chest tightness, or trouble breathing
dizziness, fainting, fast or weak heartbeat, or feeling nervous
reddening of the face, itching, hives, or feeling warm
swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing
runny nose or sneezing

Do not receive KALBITOR if you are allergic to KALBITOR. Before receiving KALBITOR, tell your doctor if you have ever had an allergic reaction to KALBITOR.

Before receiving KALBITOR, tell your doctor about all of your health conditions, including any allergies you may have, whether you are pregnant, plan to become pregnant, or are breast feeding or plan to breast feed. It is not known if KALBITOR will harm your unborn baby or if KALBITOR passes into your breast milk.

Common side effects of KALBITOR include headache, nausea, diarrhea, fever, injection site reactions, such as redness, rash, swelling, itching, or bruising, and stuffy nose.

Talk to your doctor for more information and if you have any questions about your treatment.

Please see Full Prescribing Information, including Boxed Warning and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

kalbitor ecallantide

Where HAE Attacks Happen

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Important Safety Information