Acute attacks
Sudden attacks of hereditary angioedema.
Clinical trials
Studies that evaluate the effectiveness and safety of medications or medical devices before they are approved for use by the general public.
Ecallantide (e-KAL-lan-tide)
A protein made in yeast cells; ecallantide is the active ingredient in KALBITOR (ecallantide).
Abbreviation for hereditary angioedema.
Hereditary Angioedema
A rare, hereditary disease of the immune system that causes attacks of sudden swelling in various parts of the body.
KALBITOR Home Infusion Services®
KALBITOR Home Infusion Services is a program in which an experienced infusion nurse will administer your subcutaneous KALBITOR treatment in the comfort of your own home. This professional service is available to HAE patients, 12 years of age or older, who use KALBITOR to treat their sudden HAE attacks on demand. KALBITOR Home Infusion Services is not appropriate for treating laryngeal attacks.
KALBITOR® (KAL-bit-or)
A prescription medicine used to treat sudden attacks of hereditary angioedema in patients 12 years of age and older. KALBITOR® is not a cure for HAE.
Laryngeal attack
An HAE attack that affects the larynx (throat); this can block or close the airway, leading to difficulty breathing and, potentially, death.
The part of the throat that contains the vocal cords and is used for breathing, swallowing, and talking.
On-demand treatment
On-demand HAE treatment is used to treat sudden attacks of HAE as they occur, in order to relieve symptoms associated with the attack. On-demand treatment is not used to prevent attacks from occurring.
PATHWAYS 360 is a program that provides comprehensive, personalized support services to hereditary angioedema patients. Each patient works with a program case manager who guides the patient through their entire treatment journey with KALBITOR® (ecallantide), including health insurance support, financial assistance, treatment location coordination, and much more.
Plasma kallikrein (kal'i-kre'in)
A protein in the body that triggers the release of a substance that may lead to hereditary angioedema attack symptoms.
Under the skin.
In hereditary angioedema, something that causes an attack.
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Don't Go It Alone

Living with hereditary angioedema (HAE) can be hard. That's why PATHWAYS 360SM is here to support you throughout your entire treatment journey with KALBITOR® (ecallantide). From treatment coordination to financial assistance, PATHWAYS 360 is available to you 24/7.

Please see Full Prescribing Information, including Boxed Warning and Medication Guide.

Getting Started with PATHWAYS 360SM

Once you and your doctor have decided that KALBITOR® (ecallantide) is the right option for treating your sudden hereditary angioedema (HAE) attacks, enroll in PATHWAYS 360SM and begin receiving resources and support by following two easy steps.

Step 1

Review and complete the PATHWAYS 360 Patient Authorization Form (also available through your provider).

Step 2

FAX the completed form to PATHWAYS 360 at 1-888-806-4829.
CALL PATHWAYS 360 at 1-888-4KALBITOR (1-888-452-5248) for details on completing through electronic signature.

Care to Assist You with Your Treatment

Once your form is received, your program case manager, who is also a registered nurse, will provide:

  • PERSONALIZED SUPPORT. As your main point of contact, your case manager will work closely with you to help you receive KALBITOR treatment for your HAE.
  • HEALTH INSURANCE NAVIGATION. Your case manager will help you find out about your health insurance benefits, how much KALBITOR treatment will cost you (copayments or deductibles) and information needed by your health insurance company.
  • FINANCIAL ASSISTANCE. If you cannot afford KALBITOR, your case manager will help you find out if you qualify for programs that help pay for treatment with KALBITOR and other costs not covered by insurance.
  • TREATMENT SITE COORDINATION. Your case manager will find and set up treatment sites to ensure that you receive KALIBTOR by a trained medical expert.
  • SPECIALTY PHARMACY COORDINATION. When your treatment sites are selected, your case manager will make sure that your KALBITOR is shipped to your treatment site(s) from your specialty pharmacy. 

Download the PATHWAYS 360 Patient Authorization Form to enroll today. 

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Important Safety
Information for KALBITOR.

safety information

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KALBITOR is a prescription medicine used to treat sudden attacks of hereditary angioedema (HAE) in people 12 years of age and older. KALBITOR is not a cure for HAE.
Important Safety Information

KALBITOR® (ecallantide) for subcutaneous use should only be given by a doctor or nurse with appropriate medical support to treat serious allergic reactions and your hereditary angioedema. You should read the Medication Guide before you start receiving KALBITOR and before each treatment.

Serious allergic reactions may happen in some people who receive KALBITOR. These allergic reactions can be life-threatening and usually happen within 1 hour after receiving KALBITOR.

Symptoms of a serious allergic reaction to KALBITOR can be similar to the symptoms of hereditary angioedema, the condition that you are being treated for. Your doctor or nurse should watch you for any signs of a serious allergic reaction after treatment with KALBITOR. Tell your doctor or nurse right away if you have any of these symptoms of a serious allergic reaction during or after treatment with KALBITOR:

  • wheezing, shortness of breath, cough, chest tightness, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat, or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing
  • runny nose, nasal congestion or sneezing

Do not receive KALBITOR if you are allergic to KALBITOR. Before receiving KALBITOR, tell your doctor if you have ever had an allergic reaction to KALBITOR.

Before receiving KALBITOR, tell your doctor about all of your health conditions, including any allergies you may have, whether you are pregnant, plan to become pregnant, or are breast feeding or plan to breast feed. It is not known if KALBITOR will harm your unborn baby or if KALBITOR passes into your breast milk. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Common side effects of KALBITOR include headache, nausea, diarrhea, fever, injection site reactions, such as redness, rash, swelling, itching, or bruising, and stuffy nose.

Talk to your doctor for more information and if you have any questions about your treatment.

Please see the Full Prescribing Information, including Boxed Warning and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.