How KALBITOR (ecallantide) Works
What is KALBITOR?
KALBITOR is approved to treat hereditary angioedema (HAE) attacks in patients 12 years of age and older. KALBITOR is not a cure for HAE.
KALBITOR is an on-demand treatment that targets plasma kallikrein.
How Does KALBITOR Work?
KALBITOR inhibits the activity of a protein in the body called plasma kallikrein. In patients with HAE, plasma kallikrein activity is not controlled properly.
During an HAE Attack:
- A protein called plasma kallikrein triggers the production of bradykinin that causes vessels to release fluid, resulting in localized swelling and pain.
After Treatment with KALBITOR:
- KALBITOR works by inhibiting plasma kallikrein, which stops the production of bradykinin to reduce the pain and swelling of an HAE attack.
Patients treated with KALBITOR showed significant improvement in HAE attack symptoms at 4 hours compared to patients who were treated with placebo.
About KALBITOR Injections
KALBITOR injections should only be given by a doctor or a nurse with appropriate medical support to manage serious allergic reactions and HAE. For each dose, your doctor or nurse will inject KALBITOR just under your skin, away from the site of the attack and into the abdomen, thigh, or upper arm.
Serious allergic reactions have been known to occur in patients treated with KALBITOR. These reactions can be life-threatening and usually happen within 1 hour after receiving KALBITOR. See potential side effects.
Please read the Medication Guide before you start receiving KALBITOR and before each treatment. There may be new information.