What Is Hereditary Angioedema (HAE)?

HAE is a rare, potentially life-threatening genetic disorder. Stay educated about the disease and keep the conversation going with your doctor about the best treatment plan for you.

Symptoms and Diagnosis

Hereditary angioedema (HAE) attacks typically happen in three main places in the body:

KALBITOR was studied in people with: abdominal attacks, laryngeal attacks (throat), and peripheral attacks (face, hands, genitals, and feet)

Attacks usually affect just one part of the body, such as swelling only in the hand. But it's not uncommon for more than one part of the body to be affected during a single attack, such as swelling in the hand as well as in the abdomen.

Swelling in the throat is considered to be the most dangerous and can even block a person's breathing. 50% of all people with HAE are expected to experience a throat attack in their lifetime.

KALBITOR (ecallantide) is the first under the skin (subcutaneous) treatment approved for attacks of hereditary angioedema (HAE) in patients 12 years of age and older. KALBITOR is not a cure for HAE.

KALBITOR is approved to treat attacks in all locations — including the face, hands, feet, genitals, abdomen and throat. Learn more about how KALBITOR works.

Talk to Your Doctor to Be Prepared

Although there is no known cure for hereditary angioedema (HAE), you do have treatment options. Experts recommend that all people with HAE have an on-demand therapy as a part of their treatment plan and are evaluated for long-term preventive treatment at every doctor's visit, or at least once a year. Work together with your doctor to develop a treatment plan that's right for you.

If You Think You Have HAE, You May Want to Ask Your Doctor:

  • How is HAE diagnosed?
  • Can HAE be mistaken for other conditions?
  • Could I have inherited HAE from my parents?
  • How is HAE treated?

If You Have Been Diagnosed with HAE, You May Want to Ask Your Doctor:

  • What treatments are available for HAE?
  • What are the side effects of these treatments?
  • How effective are these treatments?
  • What should I do if an HAE attack affects my breathing?
  • If I'm going to travel, what plans should I make?
  • Will I pass HAE on to my children?
  • Am I a candidate for acute or preventive treatment?

Ask your doctor if KALBITOR (ecallantide) is right for you. Read some common questions about KALBITOR.

Important Safety Information

What is the most important information I should know about KALBITOR?
Serious allergic reactions may happen in some people who receive KALBITOR. These allergic reactions can be life-threatening and usually happen within 1 hour after receiving KALBITOR.

  • KALBITOR should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions and hereditary angioedema (HAE) can be treated.
  • Symptoms of a serious allergic reaction to KALBITOR can be similar to the symptoms of HAE, the condition that you are being treated for. Your doctor or nurse should watch you for any signs of a serious allergic reaction after treatment with KALBITOR.
  • Tell your doctor or nurse right away if you have any of these symptoms of a serious allergic reaction during or after treatment with KALBITOR:
    • wheezing, shortness of breath, cough, chest tightness, or trouble breathing
    • dizziness, fainting, fast or weak heartbeat, or feeling nervous
    • reddening of the face, itching, hives, or feeling warm
    • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing
    • runny nose, nasal congestion, or sneezing

Who should not receive KALBITOR?
Do not receive KALBITOR if you are allergic to KALBITOR. Before receiving KALBITOR, tell your doctor if you have ever had an allergic reaction to KALBITOR.

What else should I tell my doctor before I receive KALBITOR?
Tell your doctor if you are pregnant, plan to become pregnant, breast-feeding, or plan to breast-feed. It is not known if KALBITOR will harm your unborn baby or pass into your breast milk.

Tell your doctor about all the medicines you take, including prescriptions and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects?
Common side effects of KALBITOR include headache, nausea, diarrhea, fever, injection site reactions, such as redness, rash, swelling, itching, or bruising, and stuffy nose. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Talk to your doctor for more information about your medical condition or treatment.

Please see the Full Prescribing Information, including Boxed Warning and Medication Guide.